(50ml)

Medik8 Pretox 10 ®

Injection-Free alternative to Botulinum Toxin treatment

Muscle Relaxant Gel in Liposome Delivery System.

Muscles contract when they receive a neurotransmitter release from a nerve. Like Botulinum Toxin A, Pretox releases the amount of nerve stimulation on the local muscle tissue being targeted but unlike Botulinum Toxin A, Pretox does not paralyse the muscle completely.

Instead it gently and temporarily reduces the strength of specific muscle contractions, thus the formulation of new lines and wrinkles is reduced and old lines appear much less prominent - leaving you with smoother younger looking skin.

Directions

Apply twice daily to clean dry skin. Product should be used sparingly on targeted areas, avoiding upper & lower eyelids and lips. Allow to absorb for 3-5 minutes before applying solution-based products, hydrator, sunscreen or make-up.

We endorse the use of sun protection. Pretox 10 may be used as a stand alone treatment.

Advanced Explanation Before you can understand how Pretox works, you need to be familiar with how muscle contractions are stimulated. Remember, it is the attenuation or muting of muscle contraction in the facial muscle groups which allows wrinkles to 'flatten out' and become much less visible. The following is for educational purposes only. hover over the steps 1 - 5 below

Results & Science

• Pretox® contains an inoffensive hexapeptide composed of natural amino acids
• It is a safe and relatively inexpensive alternative to harsh, muscle paralysis treatment
• Stimulates the skin fibroblasts in order to reconstitute the extracellular matrix
• Leads to the synthesis of collagen I and IV, fibronectine and glycosaminoglycans (GAGs)
• Stimulates wound healing and gene expression, without the pro-inflammatory reactions of other treatments

Showing the forehead before treatment with Pretox 10®	Showing the forehead after 30 days treatment with Pretox 10®
Showing the eye before treatment with Pretox 10®	Showing the eye after 30 days treatment with Pretox 10®

Pretox® reduces the depth of the wrinkles in the face caused by the contraction of the muscles of facial expression, especially in the forehead & around the eyes. It prevents the ageing of skin induced by repeated facial movements caused by excessive catecholamine release. This graph (left) shows the effect that Pretox has on the release of catecholamine, compared to a related peptide. Clinical tests have shown that Pretox® inhibits the SNARE Complex in ageing skin. The graph below shows tests carried out comparing Pretox 10® with 6 other brands of peptides with regard to the percentage formation of the SNARE Complex

As is clearly visible, Pretox 10, in a similar way to Botulinum Toxin A, inhibits SNARE complex formation, that is to say muscle contraction to a greater extent than the control and other related peptides. In fact, Pretox 10 is up to 70% more effective at reducing muscle stimulation than others available.